More research on the psychological and social consequences is desirable, since NIPT might become a part of prenatal care in many countries. Of note, it is not planned to be used as a routine screening test.
It is important to make expecting parents aware of possible short- and long-term psychological and social consequences. The mapping of studies that analyze psychological and social consequences of NIPT is one step toward identifying research gaps and encouraging new research so that there will be a sound empirical basis that both physicians and parents can use to make fully informed decisions on the use of NIPT. The dataset used and analyzed during the current study is available from the corresponding author on reasonable request.
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Skrzypek H, Hui L. Noninvasive prenatal testing for fetal aneuploidy and single gene disorders. Non-invasive prenatal testing using fetal DNA. Molecular Diagnosis Ther. Download references. The funders did not play a role in the design of this study, or in the collection, analysis, or interpretation of the data, or in the writing of the manuscript. You can also search for this author in PubMed Google Scholar. All authors have read and approved the manuscript. Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.
Reprints and Permissions. Psychological and social consequences of non-invasive prenatal testing NIPT : a scoping review. BMC Pregnancy Childbirth 19, Download citation. Received : 23 May Medical education. Volume Issue 2. Non-invasive prenatal testing: the new era in reproductive medicine.
Med J Aust ; 2 : Topics Women's health. Caveats and limitations NIPT is not without its limitations. View this article on Wiley Online Library. Correspondence: caroline. Competing interests:. First-trimester combined screening for Down syndrome and other fetal anomalies. Obstet Gynecol ; Community-based screening for Down's syndrome in the first trimester using ultrasound and maternal biochemistry.
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DNA sequencing versus standard prenatal aneuploidy screening. N Engl J Med ; Analysis of cell-free DNA in maternal blood in screening for fetal aneuploidies: updated meta-analysis. Ultrasound Obstet Gynecol ; Prenatal screening for Down syndrome in Australia: costs and benefits of current and novel screening strategies. A cost-effectiveness analysis comparing different strategies to implement noninvasive prenatal testing into a Down syndrome screening program.
Clinical implementation of cell-free DNA based aneuploidy screening: perspectives from a national audit. Ultrasound Obstet Gynecol. Dickinson JE. Sometimes a definite diagnosis can be provided, but even in those cases, the phenotypic presentation how the condition would affect a child can vary greatly. Some results will indicate only an increased risk of a condition. Other kinds of results are so rare or poorly understood that it is difficult to be sure what if any impact the genetic difference would have on a child.
In response to these technological advances and the diverse nature of the information that can be returned to patients, policies and practices are being revised and, in some cases new policies are being developed. Data Interpretation: Current genetic technologies can read at the chromosomal karyotyping and fluorescent in situ hybridization , sub-chromosomal chromosomal microarray analysis and nucleotide base pair sequencing levels.
Policy and Law: Policies and laws impacting prenatal screening and diagnostic include guidance specific to prenatal testing e.
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